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BDBM50308069 1-Isopropyl-4-(4-isopropoxy-phenyl)-6-methoxy-1H-quinazolin-2-one::CHEMBL591193

SMILES: COc1ccc2n(C(C)C)c(=O)nc(-c3ccc(OC(C)C)cc3)c2c1

InChI Key: InChIKey=YWBFSXVCNYSYAV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308069   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50308069
PNG
(1-Isopropyl-4-(4-isopropoxy-phenyl)-6-methoxy-1H-q...)
Show SMILES COc1ccc2n(C(C)C)c(=O)nc(-c3ccc(OC(C)C)cc3)c2c1
Show InChI InChI=1S/C21H24N2O3/c1-13(2)23-19-11-10-17(25-5)12-18(19)20(22-21(23)24)15-6-8-16(9-7-15)26-14(3)4/h6-14H,1-5H3
PDB

UniProtKB/SwissProt

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GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...


J Med Chem 53: 2250-63 (2010)


Article DOI: 10.1021/jm901811v
BindingDB Entry DOI: 10.7270/Q2Q240BT
More data for this
Ligand-Target Pair