BDBM50308071 4-(1-Isopropyl-6-methoxy-2-oxo-1,2,3,4-tetrahydro-quinazolin-4-yl)-benzoic acid::CHEMBL598646

SMILES: COc1ccc2n(C(C)C)c(=O)nc(-c3ccc(cc3)C(O)=O)c2c1

InChI Key: InChIKey=NAAWQOHVQWCIPP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308071   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM50308071 (4-(1-Isopropyl-6-methoxy-2-oxo-1,2,3,4-tetrahydro-...) Show SMILES COc1ccc2n(C(C)C)c(=O)nc(-c3ccc(cc3)C(O)=O)c2c1 Show InChI InChI=1S/C19H18N2O4/c1-11(2)21-16-9-8-14(25-3)10-15(16)17(20-19(21)24)12-4-6-13(7-5-12)18(22)23/h4-11H,1-3H3,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...				J Med Chem 53: 2250-63 (2010) Article DOI: 10.1021/jm901811v BindingDB Entry DOI: 10.7270/Q2Q240BT
					More data for this Ligand-Target Pair