BDBM50308073 1-Isopropyl-4-(4-isopropyl-phenyl)-6-propoxy-1H-quinazolin-2-one::CHEMBL599467

SMILES: CCCOc1ccc2n(C(C)C)c(=O)nc(-c3ccc(cc3)C(C)C)c2c1

InChI Key: InChIKey=XJVMUDHCGJXMHI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308073   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM50308073 (1-Isopropyl-4-(4-isopropyl-phenyl)-6-propoxy-1H-qu...) Show SMILES CCCOc1ccc2n(C(C)C)c(=O)nc(-c3ccc(cc3)C(C)C)c2c1 Show InChI InChI=1S/C23H28N2O2/c1-6-13-27-19-11-12-21-20(14-19)22(24-23(26)25(21)16(4)5)18-9-7-17(8-10-18)15(2)3/h7-12,14-16H,6,13H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...				J Med Chem 53: 2250-63 (2010) Article DOI: 10.1021/jm901811v BindingDB Entry DOI: 10.7270/Q2Q240BT
					More data for this Ligand-Target Pair