BDBM50308077 1-Isopropyl-4-(4-isopropyl-phenyl)-6-(2-methyl-allyloxy)-1H-quinazolin-2-one::CHEMBL599229

SMILES: CC(C)c1ccc(cc1)-c1nc(=O)n(C(C)C)c2ccc(OCCC=C)cc12

InChI Key: InChIKey=WYDMHZLLXAXGLZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308077   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM50308077 (1-Isopropyl-4-(4-isopropyl-phenyl)-6-(2-methyl-all...) Show SMILES CC(C)c1ccc(cc1)-c1nc(=O)n(C(C)C)c2ccc(OCCC=C)cc12 Show InChI InChI=1S/C24H28N2O2/c1-6-7-14-28-20-12-13-22-21(15-20)23(25-24(27)26(22)17(4)5)19-10-8-18(9-11-19)16(2)3/h6,8-13,15-17H,1,7,14H2,2-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...				J Med Chem 53: 2250-63 (2010) Article DOI: 10.1021/jm901811v BindingDB Entry DOI: 10.7270/Q2Q240BT
					More data for this Ligand-Target Pair