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SMILES: CCNc1ccc2n(C(C)C)c(=O)nc(-c3ccc(cc3)C(C)C)c2c1

InChI Key: InChIKey=OSJFKSZZQVBJRR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308094   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50308094
PNG
(6-(Ethylamino)-1-isopropyl-4-(4-isopropyl-phenyl)-...)
Show SMILES CCNc1ccc2n(C(C)C)c(=O)nc(-c3ccc(cc3)C(C)C)c2c1
Show InChI InChI=1S/C22H27N3O/c1-6-23-18-11-12-20-19(13-18)21(24-22(26)25(20)15(4)5)17-9-7-16(8-10-17)14(2)3/h7-15,23H,6H2,1-5H3
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Article
PubMed
n/an/a 460n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...

J Med Chem 53: 2250-63 (2010)


Article DOI: 10.1021/jm901811v
BindingDB Entry DOI: 10.7270/Q2Q240BT
More data for this
Ligand-Target Pair