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SMILES: CC(C)c1ccc(cc1)-c1nc(=O)n(C(C)C)c2ccc(cc12)N(CC#C)CC#C

InChI Key: InChIKey=LDTKJMBKBTVMFK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308101   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50308101
PNG
(6-Dipropargylamino-1-isopropyl-4-(4-isopropyl-phen...)
Show SMILES CC(C)c1ccc(cc1)-c1nc(=O)n(C(C)C)c2ccc(cc12)N(CC#C)CC#C
Show InChI InChI=1S/C26H27N3O/c1-7-15-28(16-8-2)22-13-14-24-23(17-22)25(27-26(30)29(24)19(5)6)21-11-9-20(10-12-21)18(3)4/h1-2,9-14,17-19H,15-16H2,3-6H3
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n/an/a 120n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...

J Med Chem 53: 2250-63 (2010)


Article DOI: 10.1021/jm901811v
BindingDB Entry DOI: 10.7270/Q2Q240BT
More data for this
Ligand-Target Pair