BDBM50308183 1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]azetidin-3-amine::CHEMBL598443

SMILES: NC1CN(C1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12

InChI Key: InChIKey=PEENLCMAOCPFKF-UHFFFAOYSA-N

Data: 2 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50308183   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50308183 (1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]azetidin...) Show SMILES NC1CN(C1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C20H18N4O2S/c21-14-11-24(12-14)15-8-9-18-17(10-15)20(23-22-18)27(25,26)19-7-3-5-13-4-1-2-6-16(13)19/h1-10,14H,11-12,21H2,(H,22,23)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5HT6 receptor by scintillation counting				J Med Chem 53: 2521-7 (2010) Article DOI: 10.1021/jm901674f BindingDB Entry DOI: 10.7270/Q22B8Z43
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50308183 (1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]azetidin...) Show SMILES NC1CN(C1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C20H18N4O2S/c21-14-11-24(12-14)15-8-9-18-17(10-15)20(23-22-18)27(25,26)19-7-3-5-13-4-1-2-6-16(13)19/h1-10,14H,11-12,21H2,(H,22,23)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	97.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting				J Med Chem 53: 2521-7 (2010) Article DOI: 10.1021/jm901674f BindingDB Entry DOI: 10.7270/Q22B8Z43
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50308183 (1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]azetidin...) Show SMILES NC1CN(C1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C20H18N4O2S/c21-14-11-24(12-14)15-8-9-18-17(10-15)20(23-22-18)27(25,26)19-7-3-5-13-4-1-2-6-16(13)19/h1-10,14H,11-12,21H2,(H,22,23)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP formation by RIA				J Med Chem 53: 2521-7 (2010) Article DOI: 10.1021/jm901674f BindingDB Entry DOI: 10.7270/Q22B8Z43
					More data for this Ligand-Target Pair