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SMILES: Oc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1Cl

InChI Key: InChIKey=NKTDDFFCFNHRMA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50308189   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50308189 (2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrim...) Show SMILES Oc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1Cl Show InChI InChI=1S/C18H13ClN4O2/c19-13-8-11(5-6-15(13)24)21-18-20-9-10-7-16(25)22-14-4-2-1-3-12(14)17(10)23-18/h1-6,8-9,24H,7H2,(H,22,25)(H,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50308189 (2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrim...) Show SMILES Oc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1Cl Show InChI InChI=1S/C18H13ClN4O2/c19-13-8-11(5-6-15(13)24)21-18-20-9-10-7-16(25)22-14-4-2-1-3-12(14)17(10)23-18/h1-6,8-9,24H,7H2,(H,22,25)(H,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50308189 (2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrim...) Show SMILES Oc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1Cl Show InChI InChI=1S/C18H13ClN4O2/c19-13-8-11(5-6-15(13)24)21-18-20-9-10-7-16(25)22-14-4-2-1-3-12(14)17(10)23-18/h1-6,8-9,24H,7H2,(H,22,25)(H,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of VEGFR2 in HUE cells assessed as inhibition of VEGF-induced autophosphorylation treated for 90 mins before VEGF challenge by ELISA				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50308189 (2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrim...) Show SMILES Oc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1Cl Show InChI InChI=1S/C18H13ClN4O2/c19-13-8-11(5-6-15(13)24)21-18-20-9-10-7-16(25)22-14-4-2-1-3-12(14)17(10)23-18/h1-6,8-9,24H,7H2,(H,22,25)(H,20,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair