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BDBM50308558 3-(4-ethylpiperazin-1-yl)-1-(2-propoxyethyl)-7-(6-methoxypyridin-3-yl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL590280

SMILES: CCCOCCn1c2cc(ncc2nc(N2CCN(CC)CC2)c1=O)-c1ccc(OC)nc1

InChI Key: InChIKey=YIDUAHHKCUXUPG-UHFFFAOYSA-N

Data: 2 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50308558   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50308558
PNG
(3-(4-ethylpiperazin-1-yl)-1-(2-propoxyethyl)-7-(6-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CC)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O3/c1-4-13-33-14-12-30-21-15-19(18-6-7-22(32-3)26-16-18)25-17-20(21)27-23(24(30)31)29-10-8-28(5-2)9-11-29/h6-7,15-17H,4-5,8-14H2,1-3H3
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 320n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch-clamp method


J Med Chem 53: 2656-60 (2010)

More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50308558
PNG
(3-(4-ethylpiperazin-1-yl)-1-(2-propoxyethyl)-7-(6-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CC)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O3/c1-4-13-33-14-12-30-21-15-19(18-6-7-22(32-3)26-16-18)25-17-20(21)27-23(24(30)31)29-10-8-28(5-2)9-11-29/h6-7,15-17H,4-5,8-14H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.220n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)

More data for this
Ligand-Target Pair