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BDBM50308759 5-(4-Fluoro-3-methylphenyl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)-2-(trifluoromethyl)-1H-imidazole-4-carboxamide::CHEMBL589603

SMILES: Cc1ccc(NC(=O)c2[nH]c(nc2-c2ccc(F)c(C)c2)C(F)(F)F)cc1Nc1ccc2ncn(C)c(=O)c2c1

InChI Key: InChIKey=NLSAILJNHVUDOU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308759   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50308759
PNG
(5-(4-Fluoro-3-methylphenyl)-N-(4-methyl-3-(3-methy...)
Show SMILES Cc1ccc(NC(=O)c2[nH]c(nc2-c2ccc(F)c(C)c2)C(F)(F)F)cc1Nc1ccc2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C28H22F4N6O2/c1-14-4-6-18(12-22(14)34-17-7-9-21-19(11-17)26(40)38(3)13-33-21)35-25(39)24-23(36-27(37-24)28(30,31)32)16-5-8-20(29)15(2)10-16/h4-13,34H,1-3H3,(H,35,39)(H,36,37)
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assay


Bioorg Med Chem 18: 292-304 (2010)


Article DOI: 10.1016/j.bmc.2009.10.055
BindingDB Entry DOI: 10.7270/Q2SQ90H4
More data for this
Ligand-Target Pair