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BDBM50308765 2-tert-Butyl-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)-5-p-tolyl-1H-imidazole-4-carboxamide::CHEMBL591276

SMILES: Cc1ccc(cc1)-c1nc([nH]c1C(=O)Nc1ccc(C)c(Nc2ccc3ncn(C)c(=O)c3c2)c1)C(C)(C)C

InChI Key: InChIKey=QIMIVUKEHRRLAM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308765   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50308765
PNG
(2-tert-Butyl-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dih...)
Show SMILES Cc1ccc(cc1)-c1nc([nH]c1C(=O)Nc1ccc(C)c(Nc2ccc3ncn(C)c(=O)c3c2)c1)C(C)(C)C
Show InChI InChI=1S/C31H32N6O2/c1-18-7-10-20(11-8-18)26-27(36-30(35-26)31(3,4)5)28(38)34-22-12-9-19(2)25(16-22)33-21-13-14-24-23(15-21)29(39)37(6)17-32-24/h7-17,33H,1-6H3,(H,34,38)(H,35,36)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 96n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assay


Bioorg Med Chem 18: 292-304 (2010)


Article DOI: 10.1016/j.bmc.2009.10.055
BindingDB Entry DOI: 10.7270/Q2SQ90H4
More data for this
Ligand-Target Pair