BDBM50309110 2-(3-(4-methyl-1,4-diazepan-1-yl)-5-(pyridin-4-yl)pyrazin-2-ylamino)ethanol::CHEMBL589337
SMILES: CN1CCCN(CC1)c1nc(cnc1NCCO)-c1ccncc1
InChI Key: InChIKey=QQNMOYJOWGKMCM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50309110 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50309110
(2-(3-(4-methyl-1,4-diazepan-1-yl)-5-(pyridin-4-yl)...)Show InChI InChI=1S/C17H24N6O/c1-22-8-2-9-23(11-10-22)17-16(19-7-12-24)20-13-15(21-17)14-3-5-18-6-4-14/h3-6,13,24H,2,7-12H2,1H3,(H,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant ROCK1 |
Bioorg Med Chem Lett 20: 1137-40 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.012
BindingDB Entry DOI: 10.7270/Q2QR4X7J |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50309110
(2-(3-(4-methyl-1,4-diazepan-1-yl)-5-(pyridin-4-yl)...)Show InChI InChI=1S/C17H24N6O/c1-22-8-2-9-23(11-10-22)17-16(19-7-12-24)20-13-15(21-17)14-3-5-18-6-4-14/h3-6,13,24H,2,7-12H2,1H3,(H,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant ROCK2 |
Bioorg Med Chem Lett 20: 1137-40 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.012
BindingDB Entry DOI: 10.7270/Q2QR4X7J |
More data for this
Ligand-Target Pair | |
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