null

SMILES: C1CCN(C1)c1ncc(nc1N1CCCNCC1)-c1ccnc2[nH]ccc12

InChI Key: InChIKey=XQDLITNOVPCUMD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50309122   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50309122 (4-(6-(1,4-diazepan-1-yl)-5-(pyrrolidin-1-yl)pyrazi...) Show SMILES C1CCN(C1)c1ncc(nc1N1CCCNCC1)-c1ccnc2[nH]ccc12 Show InChI InChI=1S/C20H25N7/c1-2-11-26(10-1)19-20(27-12-3-6-21-9-13-27)25-17(14-24-19)15-4-7-22-18-16(15)5-8-23-18/h4-5,7-8,14,21H,1-3,6,9-13H2,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of human recombinant ROCK1				Bioorg Med Chem Lett 20: 1137-40 (2010) Article DOI: 10.1016/j.bmcl.2009.12.012 BindingDB Entry DOI: 10.7270/Q2QR4X7J
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50309122 (4-(6-(1,4-diazepan-1-yl)-5-(pyrrolidin-1-yl)pyrazi...) Show SMILES C1CCN(C1)c1ncc(nc1N1CCCNCC1)-c1ccnc2[nH]ccc12 Show InChI InChI=1S/C20H25N7/c1-2-11-26(10-1)19-20(27-12-3-6-21-9-13-27)25-17(14-24-19)15-4-7-22-18-16(15)5-8-23-18/h4-5,7-8,14,21H,1-3,6,9-13H2,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of human recombinant ROCK2				Bioorg Med Chem Lett 20: 1137-40 (2010) Article DOI: 10.1016/j.bmcl.2009.12.012 BindingDB Entry DOI: 10.7270/Q2QR4X7J
					More data for this Ligand-Target Pair