BindingDB PrimarySearch

BDBM50309547 3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione::CHEMBL597492

SMILES: COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccc(I)cc12

InChI Key: InChIKey=KRICMVKKVCDVBV-UHFFFAOYSA-N

Data: 10 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50309547
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50309547 (3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Hospital Curated by ChEMBL					Assay Description Inhibition of VEGFR3 after 80 mins by radiometric protein kinase assay				Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N
Hadassah Hebrew University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50309547 (3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Hospital Curated by ChEMBL					Assay Description Inhibition of VEGFR2 after 80 mins by radiometric protein kinase assay				Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N
Hadassah Hebrew University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50309547 (3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Hospital Curated by ChEMBL					Assay Description Inhibition of VEGFR1 after 80 mins by radiometric protein kinase assay				Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N
Hadassah Hebrew University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50309547 (3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.96E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Hospital Curated by ChEMBL					Assay Description Inhibition of TIE2 after 80 mins by radiometric protein kinase assay				Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N
Hadassah Hebrew University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50309547 (3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Hospital Curated by ChEMBL					Assay Description Inhibition of ERBB2 after 80 mins by radiometric protein kinase assay				Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N
Hadassah Hebrew University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50309547 (3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Hospital Curated by ChEMBL					Assay Description Inhibition of PDGFRalpha after 80 mins by radiometric protein kinase assay				Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N
Hadassah Hebrew University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50309547 (3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Hospital Curated by ChEMBL					Assay Description Inhibition of KIT after 80 mins by radiometric protein kinase assay				Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N
Hadassah Hebrew University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50309547 (3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Hospital Curated by ChEMBL					Assay Description Inhibition of IGF1R after 80 mins by radiometric protein kinase assay				Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N
Hadassah Hebrew University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50309547 (3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Hospital Curated by ChEMBL					Assay Description Inhibition of EGFR after 80 mins by radiometric protein kinase assay				Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N
Hadassah Hebrew University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50309547 (3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	858	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Hospital Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta after 80 mins by radiometric protein kinase assay				Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N
Hadassah Hebrew University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair