BDBM50310217 7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)-2-(1-oxypyridin-3-yl)-pyrazolo[1,5-a]pyrimidine::CHEMBL599326

SMILES: [O-][n+]1cccc(c1)-c1cc2nccc(-c3ccc(OC(F)F)c(OCC4CC4)c3)n2n1

InChI Key: InChIKey=WEZKAVBVBABLRE-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50310217   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50310217 (7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...) Show SMILES [O-][n+]1cccc(c1)-c1cc2nccc(-c3ccc(OC(F)F)c(OCC4CC4)c3)n2n1 Show InChI InChI=1S/C22H18F2N4O3/c23-22(24)31-19-6-5-15(10-20(19)30-13-14-3-4-14)18-7-8-25-21-11-17(26-28(18)21)16-2-1-9-27(29)12-16/h1-2,5-12,14,22H,3-4,13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 20: 922-6 (2010) Article DOI: 10.1016/j.bmcl.2009.12.070 BindingDB Entry DOI: 10.7270/Q2SF2W9S
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50310217 (7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...) Show SMILES [O-][n+]1cccc(c1)-c1cc2nccc(-c3ccc(OC(F)F)c(OCC4CC4)c3)n2n1 Show InChI InChI=1S/C22H18F2N4O3/c23-22(24)31-19-6-5-15(10-20(19)30-13-14-3-4-14)18-7-8-25-21-11-17(26-28(18)21)16-2-1-9-27(29)12-16/h1-2,5-12,14,22H,3-4,13H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 20: 922-6 (2010) Article DOI: 10.1016/j.bmcl.2009.12.070 BindingDB Entry DOI: 10.7270/Q2SF2W9S
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50310217 (7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...) Show SMILES [O-][n+]1cccc(c1)-c1cc2nccc(-c3ccc(OC(F)F)c(OCC4CC4)c3)n2n1 Show InChI InChI=1S/C22H18F2N4O3/c23-22(24)31-19-6-5-15(10-20(19)30-13-14-3-4-14)18-7-8-25-21-11-17(26-28(18)21)16-2-1-9-27(29)12-16/h1-2,5-12,14,22H,3-4,13H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.61E+3	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of human PDE4D in U937 cells assessed as cAMP accumulation				Bioorg Med Chem Lett 20: 922-6 (2010) Article DOI: 10.1016/j.bmcl.2009.12.070 BindingDB Entry DOI: 10.7270/Q2SF2W9S
					More data for this Ligand-Target Pair