null
SMILES: CC(C)CN([C@H]1CCNC1)C(=O)c1cccc(F)c1C
InChI Key: InChIKey=NFOLOYSQMPQIMO-ZDUSSCGKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50310664 ((S)-3-fluoro-N-isobutyl-2-methyl-N-(pyrrolidin-3-y...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]5HT from human 5HT transporter expressed in HEK293 cells by scintillation counting | Bioorg Med Chem Lett 19: 5078-81 (2009) Article DOI: 10.1016/j.bmcl.2009.07.049 BindingDB Entry DOI: 10.7270/Q2JQ115V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50310664 ((S)-3-fluoro-N-isobutyl-2-methyl-N-(pyrrolidin-3-y...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]noradrenaline from human NET receptor expressed in HEK293 cells by scintillation counting | Bioorg Med Chem Lett 19: 5078-81 (2009) Article DOI: 10.1016/j.bmcl.2009.07.049 BindingDB Entry DOI: 10.7270/Q2JQ115V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50310664 ((S)-3-fluoro-N-isobutyl-2-methyl-N-(pyrrolidin-3-y...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dopamine from human DAT receptor expressed in HEK293 cells by scintillation counting | Bioorg Med Chem Lett 19: 5078-81 (2009) Article DOI: 10.1016/j.bmcl.2009.07.049 BindingDB Entry DOI: 10.7270/Q2JQ115V | |||||||||||
More data for this Ligand-Target Pair |