BDBM50311076 CHEMBL1079079::[125I]1-(2-iodophenyl)-4-cyano-5-(4-methoxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxylate
SMILES: COc1ccc(cc1)-c1c(C#N)c(nn1-c1ccccc1I)C(=O)NN1CCCCC1
InChI Key: InChIKey=WGIPGQAPFNVWIX-UHFFFAOYSA-N
Data: 7 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50311076 (CHEMBL1079079 | [125I]1-(2-iodophenyl)-4-cyano-5-(...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]CP-55940 from CB1 receptor by scintillation counting | Bioorg Med Chem Lett 19: 6209-12 (2009) Article DOI: 10.1016/j.bmcl.2009.08.092 BindingDB Entry DOI: 10.7270/Q23J3D3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50311076 (CHEMBL1079079 | [125I]1-(2-iodophenyl)-4-cyano-5-(...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]8OH-DPAT from 5HT1A receptor at 10 uM by scintillation counting | Bioorg Med Chem Lett 19: 6209-12 (2009) Article DOI: 10.1016/j.bmcl.2009.08.092 BindingDB Entry DOI: 10.7270/Q23J3D3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM50311076 (CHEMBL1079079 | [125I]1-(2-iodophenyl)-4-cyano-5-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 548 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]CP-55940 from CB2 receptor by scintillation counting | Bioorg Med Chem Lett 19: 6209-12 (2009) Article DOI: 10.1016/j.bmcl.2009.08.092 BindingDB Entry DOI: 10.7270/Q23J3D3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50311076 (CHEMBL1079079 | [125I]1-(2-iodophenyl)-4-cyano-5-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]U69593 from kappa opioid receptor at 10 uM by scintillation counting | Bioorg Med Chem Lett 19: 6209-12 (2009) Article DOI: 10.1016/j.bmcl.2009.08.092 BindingDB Entry DOI: 10.7270/Q23J3D3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50311076 (CHEMBL1079079 | [125I]1-(2-iodophenyl)-4-cyano-5-(...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]DAMGO from mu opioid at 10 uM by scintillation counting | Bioorg Med Chem Lett 19: 6209-12 (2009) Article DOI: 10.1016/j.bmcl.2009.08.092 BindingDB Entry DOI: 10.7270/Q23J3D3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50311076 (CHEMBL1079079 | [125I]1-(2-iodophenyl)-4-cyano-5-(...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO at 10 uM by scintillation counting | Bioorg Med Chem Lett 19: 6209-12 (2009) Article DOI: 10.1016/j.bmcl.2009.08.092 BindingDB Entry DOI: 10.7270/Q23J3D3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50311076 (CHEMBL1079079 | [125I]1-(2-iodophenyl)-4-cyano-5-(...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [125I]Iodoclonidine from alpha-2C adrenergic receptor at 10 uM by scintillation counting | Bioorg Med Chem Lett 19: 6209-12 (2009) Article DOI: 10.1016/j.bmcl.2009.08.092 BindingDB Entry DOI: 10.7270/Q23J3D3H | |||||||||||
More data for this Ligand-Target Pair |