null
SMILES: CCOC(=O)c1[nH]c(C)c2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12
InChI Key: InChIKey=NURBYSCFSBBMLZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM50311467 (CHEMBL1080990 | ethyl 4-(3-chloro-4-(3-fluorobenzy...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 934 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of HER2 in human SKBR3 cells by HTRF assay | Bioorg Med Chem Lett 19: 6437-40 (2009) Article DOI: 10.1016/j.bmcl.2009.09.038 BindingDB Entry DOI: 10.7270/Q25B02K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50311467 (CHEMBL1080990 | ethyl 4-(3-chloro-4-(3-fluorobenzy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of EGFR by HTRF assay | Bioorg Med Chem Lett 19: 6437-40 (2009) Article DOI: 10.1016/j.bmcl.2009.09.038 BindingDB Entry DOI: 10.7270/Q25B02K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50311467 (CHEMBL1080990 | ethyl 4-(3-chloro-4-(3-fluorobenzy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of EGFR in human A431 cells by HTRF assay | Bioorg Med Chem Lett 19: 6437-40 (2009) Article DOI: 10.1016/j.bmcl.2009.09.038 BindingDB Entry DOI: 10.7270/Q25B02K2 | |||||||||||
More data for this Ligand-Target Pair |