BDBM50311623 CHEMBL1081186::N-(5-(1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl)isoxazol-3-yl)-3,4-difluorobenzenesulfonamide

SMILES: Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2ccc(F)c(F)c2)no1

InChI Key: InChIKey=SOONLSMFDWIFKR-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50311623   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50311623 (CHEMBL1081186 | N-(5-(1-(2,4-dichlorobenzyl)-5-flu...) Show SMILES Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2ccc(F)c(F)c2)no1 Show InChI InChI=1S/C25H16Cl2F3N3O3S/c1-13-11-33(12-14-2-3-15(26)6-20(14)27)25-18(13)7-16(28)8-19(25)23-10-24(31-36-23)32-37(34,35)17-4-5-21(29)22(30)9-17/h2-11H,12H2,1H3,(H,31,32)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human EP3 receptor				Bioorg Med Chem Lett 19: 6797-800 (2009) Article DOI: 10.1016/j.bmcl.2009.09.084 BindingDB Entry DOI: 10.7270/Q2833S51
					More data for this Ligand-Target Pair
Prostanoid IP receptor (Homo sapiens (Human))	BDBM50311623 (CHEMBL1081186 | N-(5-(1-(2,4-dichlorobenzyl)-5-flu...) Show SMILES Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2ccc(F)c(F)c2)no1 Show InChI InChI=1S/C25H16Cl2F3N3O3S/c1-13-11-33(12-14-2-3-15(26)6-20(14)27)25-18(13)7-16(28)8-19(25)23-10-24(31-36-23)32-37(34,35)17-4-5-21(29)22(30)9-17/h2-11H,12H2,1H3,(H,31,32)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc Curated by ChEMBL					Assay Description Binding affinity to human IP receptor by radioligand displacement assay				Bioorg Med Chem Lett 19: 6797-800 (2009) Article DOI: 10.1016/j.bmcl.2009.09.084 BindingDB Entry DOI: 10.7270/Q2833S51
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1) (Homo sapiens (Human))	BDBM50311623 (CHEMBL1081186 | N-(5-(1-(2,4-dichlorobenzyl)-5-flu...) Show SMILES Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2ccc(F)c(F)c2)no1 Show InChI InChI=1S/C25H16Cl2F3N3O3S/c1-13-11-33(12-14-2-3-15(26)6-20(14)27)25-18(13)7-16(28)8-19(25)23-10-24(31-36-23)32-37(34,35)17-4-5-21(29)22(30)9-17/h2-11H,12H2,1H3,(H,31,32)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc Curated by ChEMBL					Assay Description Binding affinity to human EP1 receptor by radioligand displacement assay				Bioorg Med Chem Lett 19: 6797-800 (2009) Article DOI: 10.1016/j.bmcl.2009.09.084 BindingDB Entry DOI: 10.7270/Q2833S51
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50311623 (CHEMBL1081186 | N-(5-(1-(2,4-dichlorobenzyl)-5-flu...) Show SMILES Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2ccc(F)c(F)c2)no1 Show InChI InChI=1S/C25H16Cl2F3N3O3S/c1-13-11-33(12-14-2-3-15(26)6-20(14)27)25-18(13)7-16(28)8-19(25)23-10-24(31-36-23)32-37(34,35)17-4-5-21(29)22(30)9-17/h2-11H,12H2,1H3,(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor by radioligand displacement assay				Bioorg Med Chem Lett 19: 6797-800 (2009) Article DOI: 10.1016/j.bmcl.2009.09.084 BindingDB Entry DOI: 10.7270/Q2833S51
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM50311623 (CHEMBL1081186 | N-(5-(1-(2,4-dichlorobenzyl)-5-flu...) Show SMILES Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2ccc(F)c(F)c2)no1 Show InChI InChI=1S/C25H16Cl2F3N3O3S/c1-13-11-33(12-14-2-3-15(26)6-20(14)27)25-18(13)7-16(28)8-19(25)23-10-24(31-36-23)32-37(34,35)17-4-5-21(29)22(30)9-17/h2-11H,12H2,1H3,(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc Curated by ChEMBL					Assay Description Binding affinity to human EP2 receptor by radioligand displacement assay				Bioorg Med Chem Lett 19: 6797-800 (2009) Article DOI: 10.1016/j.bmcl.2009.09.084 BindingDB Entry DOI: 10.7270/Q2833S51
					More data for this Ligand-Target Pair
Prostaglandin F2-alpha receptor (Homo sapiens (Human))	BDBM50311623 (CHEMBL1081186 | N-(5-(1-(2,4-dichlorobenzyl)-5-flu...) Show SMILES Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2ccc(F)c(F)c2)no1 Show InChI InChI=1S/C25H16Cl2F3N3O3S/c1-13-11-33(12-14-2-3-15(26)6-20(14)27)25-18(13)7-16(28)8-19(25)23-10-24(31-36-23)32-37(34,35)17-4-5-21(29)22(30)9-17/h2-11H,12H2,1H3,(H,31,32)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc Curated by ChEMBL					Assay Description Binding affinity to human FP receptor by radioligand displacement assay				Bioorg Med Chem Lett 19: 6797-800 (2009) Article DOI: 10.1016/j.bmcl.2009.09.084 BindingDB Entry DOI: 10.7270/Q2833S51
					More data for this Ligand-Target Pair