null
SMILES: CN(C)CCN(C)c1cc(cc2sc(nc12)C1COc2ccccc2C1)-c1cn[nH]c1
InChI Key: InChIKey=ZXWHNSCCOSNSOJ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM50311720 (CHEMBL1081182 | N1-(2-(chroman-3-yl)-6-(1H-pyrazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 365 | n/a | n/a | n/a | n/a | n/a | n/a |
Translational Research Institute and Department of Molecular Therapeutics Curated by ChEMBL | Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay | Bioorg Med Chem Lett 19: 6686-90 (2009) Article DOI: 10.1016/j.bmcl.2009.09.115 BindingDB Entry DOI: 10.7270/Q2VX0GN0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM50311720 (CHEMBL1081182 | N1-(2-(chroman-3-yl)-6-(1H-pyrazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Translational Research Institute and Department of Molecular Therapeutics Curated by ChEMBL | Assay Description Inhibition of ROCK2 | Bioorg Med Chem Lett 19: 6686-90 (2009) Article DOI: 10.1016/j.bmcl.2009.09.115 BindingDB Entry DOI: 10.7270/Q2VX0GN0 | |||||||||||
More data for this Ligand-Target Pair |