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SMILES: Fc1cccc(CNC(=O)c2nc3ccc(cc3s2)-c2cn[nH]c2)c1

InChI Key: InChIKey=AFGOIFQBIQFJEG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50311737   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM50311737
PNG
(CHEMBL1081194 | N-(3-fluorobenzyl)-6-(1H-pyrazol-4...)
Show SMILES Fc1cccc(CNC(=O)c2nc3ccc(cc3s2)-c2cn[nH]c2)c1
Show InChI InChI=1S/C18H13FN4OS/c19-14-3-1-2-11(6-14)8-20-17(24)18-23-15-5-4-12(7-16(15)25-18)13-9-21-22-10-13/h1-7,9-10H,8H2,(H,20,24)(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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UniChem

Similars
Article
PubMed
n/an/a 72n/an/an/an/an/an/a



Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of ROCK2

Bioorg Med Chem Lett 19: 6686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.115
BindingDB Entry DOI: 10.7270/Q2VX0GN0
More data for this
Ligand-Target Pair