BindingDB PrimarySearch

BDBM50311741 1,6-dihydroxy-7-methoxy-8-(3-methylbut-2-enyl)-6',6'-dimethylpyrano(2',3':3,2)xanthone::9-hydroxycalabaxanthone::CHEMBL561643::mangostanin

SMILES: [#6]-[#8]-c1c(-[#8])cc2oc3cc4-[#8]C([#6])([#6])[#6]=[#6]-c4c(-[#8])c3c(=O)c2c1-[#6]\[#6]=[#6](\[#6])-[#6]

InChI Key: InChIKey=HQWHKELJHUFLGD-UHFFFAOYSA-N

Data: 1 KI 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50311741
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sialidase (Clostridium perfringens)	BDBM50311741 (1,6-dihydroxy-7-methoxy-8-(3-methylbut-2-enyl)-6',...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Graduate School of Gyeongsang National University Curated by ChEMBL					Assay Description Competitive inhibition of Clostridium perfringens neuraminidase by fluorometry				Bioorg Med Chem 18: 6258-64 (2010) Article DOI: 10.1016/j.bmc.2010.07.033 BindingDB Entry DOI: 10.7270/Q2BK1CK4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB) (Homo sapiens (Human))	BDBM50311741 (1,6-dihydroxy-7-methoxy-8-(3-methylbut-2-enyl)-6',...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of p50 after 1 hr by ELISA				J Nat Prod 72: 2028-31 (2009) Article DOI: 10.1021/np900517h BindingDB Entry DOI: 10.7270/Q2R49QWK
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B (Homo sapiens (Human))	BDBM50311741 (1,6-dihydroxy-7-methoxy-8-(3-methylbut-2-enyl)-6',...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of nuclear factor NF-kappa-B p65 subunit after 1 hr by ELISA				J Nat Prod 72: 2028-31 (2009) Article DOI: 10.1021/np900517h BindingDB Entry DOI: 10.7270/Q2R49QWK
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50311741 (1,6-dihydroxy-7-methoxy-8-(3-methylbut-2-enyl)-6',...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Guangzhou University of Chinese Medicine Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 (86 to 413 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins...				J Med Chem 63: 3370-3380 (2020) Article DOI: 10.1021/acs.jmedchem.0c00060
Guangzhou University of Chinese Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Probable maltase-glucoamylase 2 (Homo sapiens)	BDBM50311741 (1,6-dihydroxy-7-methoxy-8-(3-methylbut-2-enyl)-6',...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Wollongong Curated by ChEMBL					Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl alpha-D-glucoside as substrate preincubated for 0.5 hrs followed substrate addit...				J Nat Prod 83: 164-168 (2020) Article DOI: 10.1021/acs.jnatprod.9b00849
University of Wollongong Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50311741 (1,6-dihydroxy-7-methoxy-8-(3-methylbut-2-enyl)-6',...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of FAS				Bioorg Med Chem Lett 20: 6045-7 (2010) Article DOI: 10.1016/j.bmcl.2010.08.061 BindingDB Entry DOI: 10.7270/Q2TT4R6N
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Sialidase (Clostridium perfringens)	BDBM50311741 (1,6-dihydroxy-7-methoxy-8-(3-methylbut-2-enyl)-6',...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
Graduate School of Gyeongsang National University Curated by ChEMBL					Assay Description Inhibition of Clostridium perfringens neuraminidase by fluorometry				Bioorg Med Chem 18: 6258-64 (2010) Article DOI: 10.1016/j.bmc.2010.07.033 BindingDB Entry DOI: 10.7270/Q2BK1CK4
					More data for this Ligand-Target Pair