BDBM50311974 2-(1-(cyclohexylmethyl)-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4-d]pyrimidin-7-amine::2-[3-(CYCLOHEXYLMETHYL)-5-PHENYL-IMIDAZOL-4-YL]-[1,3]THIAZOLO[4,5-E]PYRIMIDIN-7-AMINE::CHEMBL1079589

SMILES: Nc1ncnc2sc(nc12)-c1c(ncn1CC1CCCCC1)-c1ccccc1

InChI Key: InChIKey=FACMGTJQTMTYEF-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50311974   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50311974 (2-(1-(cyclohexylmethyl)-4-phenyl-1H-imidazol-5-yl)...) Show SMILES Nc1ncnc2sc(nc12)-c1c(ncn1CC1CCCCC1)-c1ccccc1 Show InChI InChI=1S/C21H22N6S/c22-19-17-20(24-12-23-19)28-21(26-17)18-16(15-9-5-2-6-10-15)25-13-27(18)11-14-7-3-1-4-8-14/h2,5-6,9-10,12-14H,1,3-4,7-8,11H2,(H2,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of Tie-2 phosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6670-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.001 BindingDB Entry DOI: 10.7270/Q2FN16BJ
					More data for this Ligand-Target Pair				3D Structure (crystal)