BindingDB PrimarySearch

BDBM50312057 CHEMBL1087397::N-(3-(3-(4-((dimethylamino)methyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide::N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide

SMILES: CN(C)Cc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1

InChI Key: InChIKey=AIWJVLQNYNCDSL-UHFFFAOYSA-N

Data: 15 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50312057
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of PKCalpha				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of PDK1				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of cRAF				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	216	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of p38alpha				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of CDK4				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of IKKbeta				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of JNK1				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of MK2				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of SRC				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 6 (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of MKK6				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of PLK1				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of p70S6K				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50312057 (CHEMBL1087397 \| N-(3-(3-(4-((dimethylamino)methyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human recombinant B-Raf expressed in Sf9 cells				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)