BDBM50312154 1-(5-chloro-2-methoxyphenyl)-3-(3-(8-(methylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)urea::CHEMBL1081054

SMILES: CNc1nc(cn2ccnc12)-c1cccc(NC(=O)Nc2cc(Cl)ccc2OC)c1

InChI Key: InChIKey=HOWJUTADDWLXSE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50312154   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312154 (1-(5-chloro-2-methoxyphenyl)-3-(3-(8-(methylamino)...) Show SMILES CNc1nc(cn2ccnc12)-c1cccc(NC(=O)Nc2cc(Cl)ccc2OC)c1 Show InChI InChI=1S/C21H19ClN6O2/c1-23-19-20-24-8-9-28(20)12-17(26-19)13-4-3-5-15(10-13)25-21(29)27-16-11-14(22)6-7-18(16)30-2/h3-12H,1-2H3,(H,23,26)(H2,25,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair