BDBM50312158 1-(3-(8-aminoimidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(5-chloro-2-methoxyphenyl)urea::CHEMBL1081222

SMILES: COc1ccc(Cl)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(N)n1

InChI Key: InChIKey=IZQNYEJZWDIOFU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50312158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312158 (1-(3-(8-aminoimidazo[1,2-a]pyrazin-6-yl)phenyl)-3-...) Show SMILES COc1ccc(Cl)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(N)n1 Show InChI InChI=1S/C20H17ClN6O2/c1-29-17-6-5-13(21)10-15(17)26-20(28)24-14-4-2-3-12(9-14)16-11-27-8-7-23-19(27)18(22)25-16/h2-11H,1H3,(H2,22,25)(H2,24,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair