BDBM50312162 CHEMBL1080872::N-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(trifluoromethyl)benzenesulfonamide

SMILES: FC(F)(F)c1cccc(c1)S(=O)(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1

InChI Key: InChIKey=WZFZONITOFUGNM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50312162   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312162 (CHEMBL1080872 | N-(3-(8-(pyridin-4-ylmethylamino)i...) Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C25H19F3N6O2S/c26-25(27,28)19-4-2-6-21(14-19)37(35,36)33-20-5-1-3-18(13-20)22-16-34-12-11-30-24(34)23(32-22)31-15-17-7-9-29-10-8-17/h1-14,16,33H,15H2,(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair