BDBM50312610 6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-2-pyridin-4-yl-thieno[3,2-d]pyrimidine::CHEMBL1077023

SMILES: CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2ccncc2)CC1

InChI Key: InChIKey=MTCQVCCBRHUPNZ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50312610   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50312610 (6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...) Show SMILES CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2ccncc2)CC1 Show InChI InChI=1S/C21H26N6O3S2/c1-32(28,29)27-8-6-25(7-9-27)15-17-14-18-19(31-17)21(26-10-12-30-13-11-26)24-20(23-18)16-2-4-22-5-3-16/h2-5,14H,6-13,15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assay				J Med Chem 53: 1086-97 (2010) Article DOI: 10.1021/jm901284w BindingDB Entry DOI: 10.7270/Q2FJ2GXT
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50312610 (6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...) Show SMILES CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2ccncc2)CC1 Show InChI InChI=1S/C21H26N6O3S2/c1-32(28,29)27-8-6-25(7-9-27)15-17-14-18-19(31-17)21(26-10-12-30-13-11-26)24-20(23-18)16-2-4-22-5-3-16/h2-5,14H,6-13,15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assay				J Med Chem 53: 1086-97 (2010) Article DOI: 10.1021/jm901284w BindingDB Entry DOI: 10.7270/Q2FJ2GXT
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50312610 (6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...) Show SMILES CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2ccncc2)CC1 Show InChI InChI=1S/C21H26N6O3S2/c1-32(28,29)27-8-6-25(7-9-27)15-17-14-18-19(31-17)21(26-10-12-30-13-11-26)24-20(23-18)16-2-4-22-5-3-16/h2-5,14H,6-13,15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assay				J Med Chem 53: 1086-97 (2010) Article DOI: 10.1021/jm901284w BindingDB Entry DOI: 10.7270/Q2FJ2GXT
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50312610 (6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...) Show SMILES CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2ccncc2)CC1 Show InChI InChI=1S/C21H26N6O3S2/c1-32(28,29)27-8-6-25(7-9-27)15-17-14-18-19(31-17)21(26-10-12-30-13-11-26)24-20(23-18)16-2-4-22-5-3-16/h2-5,14H,6-13,15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assay				J Med Chem 53: 1086-97 (2010) Article DOI: 10.1021/jm901284w BindingDB Entry DOI: 10.7270/Q2FJ2GXT
					More data for this Ligand-Target Pair