BDBM50312615 2-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol::CHEMBL1083508

SMILES: CC(C)(O)c1cc2nc(nc(N3CCOCC3)c2s1)-c1cccc2[nH]ncc12

InChI Key: InChIKey=KYBJEPGFZBUXMW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50312615   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50312615 (2-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]py...) Show SMILES CC(C)(O)c1cc2nc(nc(N3CCOCC3)c2s1)-c1cccc2[nH]ncc12 Show InChI InChI=1S/C20H21N5O2S/c1-20(2,26)16-10-15-17(28-16)19(25-6-8-27-9-7-25)23-18(22-15)12-4-3-5-14-13(12)11-21-24-14/h3-5,10-11,26H,6-9H2,1-2H3,(H,21,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assay				J Med Chem 53: 1086-97 (2010) Article DOI: 10.1021/jm901284w BindingDB Entry DOI: 10.7270/Q2FJ2GXT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50312615 (2-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]py...) Show SMILES CC(C)(O)c1cc2nc(nc(N3CCOCC3)c2s1)-c1cccc2[nH]ncc12 Show InChI InChI=1S/C20H21N5O2S/c1-20(2,26)16-10-15-17(28-16)19(25-6-8-27-9-7-25)23-18(22-15)12-4-3-5-14-13(12)11-21-24-14/h3-5,10-11,26H,6-9H2,1-2H3,(H,21,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR by FRET				J Med Chem 53: 1086-97 (2010) Article DOI: 10.1021/jm901284w BindingDB Entry DOI: 10.7270/Q2FJ2GXT
					More data for this Ligand-Target Pair