BDBM50312616 2-[2-(2-Amino-4-methyl-pyrimidin-5-yl)-4-morpholin-4-yl-thieno-[3,2-d]pyrimidin-6-yl]-propan-2-ol::CHEMBL1086403
SMILES: CC(=O)NCc1cc2nc(nc(N3CCOCC3)c2s1)-c1cccc2[nH]ncc12
InChI Key: InChIKey=JSRNAKDXAPQVRG-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM50312616 (2-[2-(2-Amino-4-methyl-pyrimidin-5-yl)-4-morpholin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assay | J Med Chem 53: 1086-97 (2010) Article DOI: 10.1021/jm901284w BindingDB Entry DOI: 10.7270/Q2FJ2GXT | |||||||||||
More data for this Ligand-Target Pair |