BDBM50312618 (2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanol::CHEMBL1083506

SMILES: OCc1cc2nc(nc(N3CCOCC3)c2s1)-c1cccc2[nH]ncc12

InChI Key: InChIKey=QLUFYDHSNDOTQX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50312618   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50312618 ((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyri...) Show SMILES OCc1cc2nc(nc(N3CCOCC3)c2s1)-c1cccc2[nH]ncc12 Show InChI InChI=1S/C18H17N5O2S/c24-10-11-8-15-16(26-11)18(23-4-6-25-7-5-23)21-17(20-15)12-2-1-3-14-13(12)9-19-22-14/h1-3,8-9,24H,4-7,10H2,(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assay				J Med Chem 53: 1086-97 (2010) Article DOI: 10.1021/jm901284w BindingDB Entry DOI: 10.7270/Q2FJ2GXT
					More data for this Ligand-Target Pair