BindingDB PrimarySearch

BDBM50312906 2-(2-(bis(4-fluorophenyl)methyl)-4-(3-fluorophenyl)pyrimidin-5-yl)acetic acid::CHEMBL1088284

SMILES: OC(=O)Cc1cnc(nc1-c1cccc(F)c1)C(c1ccc(F)cc1)c1ccc(F)cc1

InChI Key: InChIKey=ACFQRXVIUVXHIY-UHFFFAOYSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50312906
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
G protein-coupled receptor 44 (Homo sapiens (Human))	BDBM50312906 (2-(2-(bis(4-fluorophenyl)methyl)-4-(3-fluorophenyl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Antagonist activity at human CRTH2 receptor expressed in HEK385-7 cells assessed as inhibition of PGD2-mediated beta-arrestin translocation preincuba...				Bioorg Med Chem Lett 20: 1638-41 (2010) Article DOI: 10.1016/j.bmcl.2010.01.092 BindingDB Entry DOI: 10.7270/Q2416X6B
7TM Pharma A/S Curated by ChEMBL					More data for this Ligand-Target Pair
G protein-coupled receptor 44 (Homo sapiens (Human))	BDBM50312906 (2-(2-(bis(4-fluorophenyl)methyl)-4-(3-fluorophenyl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells				Bioorg Med Chem Lett 20: 1638-41 (2010) Article DOI: 10.1016/j.bmcl.2010.01.092 BindingDB Entry DOI: 10.7270/Q2416X6B
7TM Pharma A/S Curated by ChEMBL					More data for this Ligand-Target Pair
G protein-coupled receptor 44 (Rattus norvegicus)	BDBM50312906 (2-(2-(bis(4-fluorophenyl)methyl)-4-(3-fluorophenyl...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibition of rat CRTH2 receptor				Bioorg Med Chem Lett 20: 1638-41 (2010) Article DOI: 10.1016/j.bmcl.2010.01.092 BindingDB Entry DOI: 10.7270/Q2416X6B
7TM Pharma A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Prostanoid TP receptor (Homo sapiens (Human))	BDBM50312906 (2-(2-(bis(4-fluorophenyl)methyl)-4-(3-fluorophenyl...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibition of thromboxane A2 receptor				Bioorg Med Chem Lett 20: 1638-41 (2010) Article DOI: 10.1016/j.bmcl.2010.01.092 BindingDB Entry DOI: 10.7270/Q2416X6B
7TM Pharma A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Chemoattractant receptor-homologous molecule expressed on Th2 cells (Cavia porcellus)	BDBM50312906 (2-(2-(bis(4-fluorophenyl)methyl)-4-(3-fluorophenyl...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibition of guinea pig CRTH2 receptor				Bioorg Med Chem Lett 20: 1638-41 (2010) Article DOI: 10.1016/j.bmcl.2010.01.092 BindingDB Entry DOI: 10.7270/Q2416X6B
7TM Pharma A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Prostanoid DP receptor (Homo sapiens (Human))	BDBM50312906 (2-(2-(bis(4-fluorophenyl)methyl)-4-(3-fluorophenyl...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibition of human DP receptor				Bioorg Med Chem Lett 20: 1638-41 (2010) Article DOI: 10.1016/j.bmcl.2010.01.092 BindingDB Entry DOI: 10.7270/Q2416X6B
7TM Pharma A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Prostanoid DP receptor (Mus musculus)	BDBM50312906 (2-(2-(bis(4-fluorophenyl)methyl)-4-(3-fluorophenyl...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibition of mouse DP receptor				Bioorg Med Chem Lett 20: 1638-41 (2010) Article DOI: 10.1016/j.bmcl.2010.01.092 BindingDB Entry DOI: 10.7270/Q2416X6B
7TM Pharma A/S Curated by ChEMBL					More data for this Ligand-Target Pair
G protein-coupled receptor 44 (Mus musculus (mouse))	BDBM50312906 (2-(2-(bis(4-fluorophenyl)methyl)-4-(3-fluorophenyl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibition of mouse CRTH2 receptor				Bioorg Med Chem Lett 20: 1638-41 (2010) Article DOI: 10.1016/j.bmcl.2010.01.092 BindingDB Entry DOI: 10.7270/Q2416X6B
7TM Pharma A/S Curated by ChEMBL					More data for this Ligand-Target Pair