BDBM50312915 2-(2-(1,1-diphenylethyl)-4-(4-fluorophenyl)thiazol-5-yl)acetic acid::CHEMBL1087622
SMILES: CC(c1nc(c(CC(O)=O)s1)-c1ccc(F)cc1)(c1ccccc1)c1ccccc1
InChI Key: InChIKey=NKUNQYZWFFFZEA-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50312915 (2-(2-(1,1-diphenylethyl)-4-(4-fluorophenyl)thiazol...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0850 | n/a | n/a | n/a | n/a | n/a | n/a |
7TM Pharma A/S Curated by ChEMBL | Assay Description Antagonist activity at human CRTH2 receptor expressed in HEK385-7 cells assessed as inhibition of PGD2-mediated beta-arrestin translocation preincuba... | Bioorg Med Chem Lett 20: 1638-41 (2010) Article DOI: 10.1016/j.bmcl.2010.01.092 BindingDB Entry DOI: 10.7270/Q2416X6B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50312915 (2-(2-(1,1-diphenylethyl)-4-(4-fluorophenyl)thiazol...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
7TM Pharma A/S Curated by ChEMBL | Assay Description Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells | Bioorg Med Chem Lett 20: 1638-41 (2010) Article DOI: 10.1016/j.bmcl.2010.01.092 BindingDB Entry DOI: 10.7270/Q2416X6B | |||||||||||
More data for this Ligand-Target Pair |