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SMILES: COc1ccc(cc1OC)-c1[nH][nH]c(=O)c1N=Nc1cccc(Cl)c1

InChI Key: InChIKey=ULLNNJONKBEIPP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50313056   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM50313056
PNG
((Z)-4-(2-(3-chlorophenyl)hydrazono)-3-(3,4-dimetho...)
Show SMILES COc1ccc(cc1OC)-c1[nH][nH]c(=O)c1N=Nc1cccc(Cl)c1 |w:16.17|
Show InChI InChI=1S/C17H15ClN4O3/c1-24-13-7-6-10(8-14(13)25-2)15-16(17(23)22-20-15)21-19-12-5-3-4-11(18)9-12/h3-9H,1-2H3,(H2,20,22,23)
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MMDB

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Similars
Article
PubMed
 0.400n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of GSK3-beta assessed as NADH level after 10 mins by pyruvate kinase/lactate dehydrogenase coupled spectrophotometric assay

Bioorg Med Chem Lett 20: 1661-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.072
BindingDB Entry DOI: 10.7270/Q2TX3G9B
More data for this
Ligand-Target Pair