BDBM50313549 CHEMBL1085197::CHEMBL1204411::{3-[1-(2-Fluoro-phenyl)-2,2-dioxo-1,2,3,4-tetrahydro-2lambda*6*-benzo[c][1,2]thiazin-3-yl]-propyl}-methyl-amine
SMILES: CNCCCC1Cc2ccccc2N(c2ccccc2F)S1(=O)=O
InChI Key: InChIKey=SPHAUOPMTCENAZ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50313549 (CHEMBL1085197 | CHEMBL1204411 | {3-[1-(2-Fluoro-ph...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells | Bioorg Med Chem Lett 20: 1555-8 (2010) Article DOI: 10.1016/j.bmcl.2010.01.056 BindingDB Entry DOI: 10.7270/Q2FN175Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50313549 (CHEMBL1085197 | CHEMBL1204411 | {3-[1-(2-Fluoro-ph...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells | Bioorg Med Chem Lett 20: 1555-8 (2010) Article DOI: 10.1016/j.bmcl.2010.01.056 BindingDB Entry DOI: 10.7270/Q2FN175Q | |||||||||||
More data for this Ligand-Target Pair |