BDBM50314068 CHEMBL1091689::N-(3-(2-(2-(3-(1H-imidazol-2-yl)propylamino)pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide

SMILES: FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccnc(NCCCc2ncc[nH]2)c1

InChI Key: InChIKey=UVOURMTZWAHXDG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50314068   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50314068 (CHEMBL1091689 | N-(3-(2-(2-(3-(1H-imidazol-2-yl)pr...) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccnc(NCCCc2ncc[nH]2)c1 Show InChI InChI=1S/C31H25F3N8O/c32-31(33,34)23-6-1-5-22(16-23)30(43)40-24-7-2-4-21(17-24)26-10-13-39-29-19-25(41-42(26)29)20-9-12-36-28(18-20)35-11-3-8-27-37-14-15-38-27/h1-2,4-7,9-10,12-19H,3,8,11H2,(H,35,36)(H,37,38)(H,40,43)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of b-Raf				Bioorg Med Chem Lett 19: 6890-2 (2009) Article DOI: 10.1016/j.bmcl.2009.10.074 BindingDB Entry DOI: 10.7270/Q2C829F3
					More data for this Ligand-Target Pair