BDBM50314329 (Z)-1-(2-((4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-5-yl)-3-methylurea::CHEMBL1093069
SMILES: CNC(=O)Nc1ccc2O\C(=C/c3cn(C)c4nccc(N5CC6CCC(C5)O6)c34)C(=O)c2c1
InChI Key: InChIKey=SWAWWPBWXKGURA-NKVSQWTQSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50314329 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50314329
((Z)-1-(2-((4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)...)Show SMILES CNC(=O)Nc1ccc2O\C(=C/c3cn(C)c4nccc(N5CC6CCC(C5)O6)c34)C(=O)c2c1 Show InChI InChI=1S/C25H25N5O4/c1-26-25(32)28-15-3-6-20-18(10-15)23(31)21(34-20)9-14-11-29(2)24-22(14)19(7-8-27-24)30-12-16-4-5-17(13-30)33-16/h3,6-11,16-17H,4-5,12-13H2,1-2H3,(H2,26,28,32)/b21-9- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha |
Bioorg Med Chem Lett 20: 2259-63 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.012 BindingDB Entry DOI: 10.7270/Q2TB1717 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50314329
((Z)-1-(2-((4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)...)Show SMILES CNC(=O)Nc1ccc2O\C(=C/c3cn(C)c4nccc(N5CC6CCC(C5)O6)c34)C(=O)c2c1 Show InChI InChI=1S/C25H25N5O4/c1-26-25(32)28-15-3-6-20-18(10-15)23(31)21(34-20)9-14-11-29(2)24-22(14)19(7-8-27-24)30-12-16-4-5-17(13-30)33-16/h3,6-11,16-17H,4-5,12-13H2,1-2H3,(H2,26,28,32)/b21-9- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of mTOR |
Bioorg Med Chem Lett 20: 2259-63 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.012 BindingDB Entry DOI: 10.7270/Q2TB1717 |
More data for this Ligand-Target Pair | |