null

SMILES: CN(Cc1ccncc1)C(=O)C1CCN(CC1)c1ccnc2n(C)cc(\C=C3/Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c12

InChI Key: InChIKey=ZOQVYJSVLWGTGV-MNBJERMJSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50314336   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50314336 ((Z)-N-methyl-1-(1-methyl-3-((3-oxo-5-(3-pyridin-3-...) Show SMILES CN(Cc1ccncc1)C(=O)C1CCN(CC1)c1ccnc2n(C)cc(\C=C3/Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c12 Show InChI InChI=1S/C36H34N8O4/c1-42-22-25(18-31-33(45)28-19-26(5-6-30(28)48-31)40-36(47)41-27-4-3-12-38-20-27)32-29(9-15-39-34(32)42)44-16-10-24(11-17-44)35(46)43(2)21-23-7-13-37-14-8-23/h3-9,12-15,18-20,22,24H,10-11,16-17,21H2,1-2H3,(H2,40,41,47)/b31-18-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of mTOR				Bioorg Med Chem Lett 20: 2259-63 (2010) Article DOI: 10.1016/j.bmcl.2010.02.012 BindingDB Entry DOI: 10.7270/Q2TB1717
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50314336 ((Z)-N-methyl-1-(1-methyl-3-((3-oxo-5-(3-pyridin-3-...) Show SMILES CN(Cc1ccncc1)C(=O)C1CCN(CC1)c1ccnc2n(C)cc(\C=C3/Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c12 Show InChI InChI=1S/C36H34N8O4/c1-42-22-25(18-31-33(45)28-19-26(5-6-30(28)48-31)40-36(47)41-27-4-3-12-38-20-27)32-29(9-15-39-34(32)42)44-16-10-24(11-17-44)35(46)43(2)21-23-7-13-37-14-8-23/h3-9,12-15,18-20,22,24H,10-11,16-17,21H2,1-2H3,(H2,40,41,47)/b31-18-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha				Bioorg Med Chem Lett 20: 2259-63 (2010) Article DOI: 10.1016/j.bmcl.2010.02.012 BindingDB Entry DOI: 10.7270/Q2TB1717
					More data for this Ligand-Target Pair