BDBM50314558 (4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)(pyrazin-2-yl)methanone::CHEMBL1090016

SMILES: O=C(N1CCN(CCCNc2nnc(-c3ccccc3)c3c2cc2ccccn32)CC1)c1cnccn1

InChI Key: InChIKey=UBFOHSDZACWGDX-UHFFFAOYSA-N

Data: 2 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50314558   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50314558 ((4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamin...) Show SMILES O=C(N1CCN(CCCNc2nnc(-c3ccccc3)c3c2cc2ccccn32)CC1)c1cnccn1 Show InChI InChI=1S/C28H28N8O/c37-28(24-20-29-11-12-30-24)35-17-15-34(16-18-35)13-6-10-31-27-23-19-22-9-4-5-14-36(22)26(23)25(32-33-27)21-7-2-1-3-8-21/h1-5,7-9,11-12,14,19-20H,6,10,13,15-18H2,(H,31,33)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50314558 ((4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamin...) Show SMILES O=C(N1CCN(CCCNc2nnc(-c3ccccc3)c3c2cc2ccccn32)CC1)c1cnccn1 Show InChI InChI=1S/C28H28N8O/c37-28(24-20-29-11-12-30-24)35-17-15-34(16-18-35)13-6-10-31-27-23-19-22-9-4-5-14-36(22)26(23)25(32-33-27)21-7-2-1-3-8-21/h1-5,7-9,11-12,14,19-20H,6,10,13,15-18H2,(H,31,33)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.37E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50314558 ((4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamin...) Show SMILES O=C(N1CCN(CCCNc2nnc(-c3ccccc3)c3c2cc2ccccn32)CC1)c1cnccn1 Show InChI InChI=1S/C28H28N8O/c37-28(24-20-29-11-12-30-24)35-17-15-34(16-18-35)13-6-10-31-27-23-19-22-9-4-5-14-36(22)26(23)25(32-33-27)21-7-2-1-3-8-21/h1-5,7-9,11-12,14,19-20H,6,10,13,15-18H2,(H,31,33)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4B3 expressed in CHO cells assessed as isoproterenol-induced [125I]cAMP accumulation after 15 mins by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50314558 ((4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamin...) Show SMILES O=C(N1CCN(CCCNc2nnc(-c3ccccc3)c3c2cc2ccccn32)CC1)c1cnccn1 Show InChI InChI=1S/C28H28N8O/c37-28(24-20-29-11-12-30-24)35-17-15-34(16-18-35)13-6-10-31-27-23-19-22-9-4-5-14-36(22)26(23)25(32-33-27)21-7-2-1-3-8-21/h1-5,7-9,11-12,14,19-20H,6,10,13,15-18H2,(H,31,33)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4D4 expressed in CHO cells assessed as isoproterenol-induced [125I]cAMP accumulation after 15 mins by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair