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BDBM50314559 CHEMBL1091807::N-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propyl)-4-m-tolylpyridazino[4,5-b]indolizin-1-amine

SMILES: Cc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12

InChI Key: InChIKey=SXIMWTLGTMJJMZ-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50314559   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50314559
PNG
(CHEMBL1091807 | N-(3-(4-(pyrimidin-2-yl)piperazin-...)
Show SMILES Cc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12
Show InChI InChI=1S/C28H30N8/c1-21-7-4-8-22(19-21)25-26-24(20-23-9-2-3-14-36(23)26)27(33-32-25)29-12-6-13-34-15-17-35(18-16-34)28-30-10-5-11-31-28/h2-5,7-11,14,19-20H,6,12-13,15-18H2,1H3,(H,29,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.30E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 2163-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.044
BindingDB Entry DOI: 10.7270/Q2NK3F54
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50314559
PNG
(CHEMBL1091807 | N-(3-(4-(pyrimidin-2-yl)piperazin-...)
Show SMILES Cc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12
Show InChI InChI=1S/C28H30N8/c1-21-7-4-8-22(19-21)25-26-24(20-23-9-2-3-14-36(23)26)27(33-32-25)29-12-6-13-34-15-17-35(18-16-34)28-30-10-5-11-31-28/h2-5,7-11,14,19-20H,6,12-13,15-18H2,1H3,(H,29,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
5.44E+4n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 2163-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.044
BindingDB Entry DOI: 10.7270/Q2NK3F54
More data for this
Ligand-Target Pair