BDBM50314563 3-(1-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propylamino)pyridazino[4,5-b]indolizin-4-yl)benzonitrile::CHEMBL1089686

SMILES: N#Cc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12

InChI Key: InChIKey=KGVFUTVFZWTLLX-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50314563   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50314563 (3-(1-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propylam...) Show SMILES N#Cc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C28H27N9/c29-20-21-6-3-7-22(18-21)25-26-24(19-23-8-1-2-13-37(23)26)27(34-33-25)30-11-5-12-35-14-16-36(17-15-35)28-31-9-4-10-32-28/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,30,34)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50314563 (3-(1-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propylam...) Show SMILES N#Cc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C28H27N9/c29-20-21-6-3-7-22(18-21)25-26-24(19-23-8-1-2-13-37(23)26)27(34-33-25)30-11-5-12-35-14-16-36(17-15-35)28-31-9-4-10-32-28/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,30,34)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.35E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair