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BDBM50314568 (4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)(phenyl)methanone::CHEMBL1090032

SMILES: Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2ccccc2)c2cc3ccccn3c12

InChI Key: InChIKey=XPGPALDGXQWXEU-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50314568   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50314568
PNG
((4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizi...)
Show SMILES Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2ccccc2)c2cc3ccccn3c12
Show InChI InChI=1S/C30H29FN6O/c31-24-11-6-10-23(20-24)27-28-26(21-25-12-4-5-15-37(25)28)29(34-33-27)32-13-7-14-35-16-18-36(19-17-35)30(38)22-8-2-1-3-9-22/h1-6,8-12,15,20-21H,7,13-14,16-19H2,(H,32,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
2.70E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 2163-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.044
BindingDB Entry DOI: 10.7270/Q2NK3F54
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50314568
PNG
((4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizi...)
Show SMILES Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2ccccc2)c2cc3ccccn3c12
Show InChI InChI=1S/C30H29FN6O/c31-24-11-6-10-23(20-24)27-28-26(21-25-12-4-5-15-37(25)28)29(34-33-27)32-13-7-14-35-16-18-36(19-17-35)30(38)22-8-2-1-3-9-22/h1-6,8-12,15,20-21H,7,13-14,16-19H2,(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
2.22E+4n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 2163-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.044
BindingDB Entry DOI: 10.7270/Q2NK3F54
More data for this
Ligand-Target Pair