BDBM50314927 1'-(7-methyl-1H-indazole-5-carbonyl)-6-(2-methyloxazol-4-yl)spiro[chroman-2,4'-piperidin]-4-one::CHEMBL1090193

SMILES: Cc1nc(co1)-c1ccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2c1

InChI Key: InChIKey=JCGKXLHCKHTFOC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50314927   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acetyl-CoA carboxylase 2 (ACC2) (Homo sapiens (Human))	BDBM50314927 (1'-(7-methyl-1H-indazole-5-carbonyl)-6-(2-methylox...) Show SMILES Cc1nc(co1)-c1ccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2c1 Show InChI InChI=1S/C26H24N4O4/c1-15-9-18(10-19-13-27-29-24(15)19)25(32)30-7-5-26(6-8-30)12-22(31)20-11-17(3-4-23(20)34-26)21-14-33-16(2)28-21/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1) (Rattus norvegicus (Rat))	BDBM50314927 (1'-(7-methyl-1H-indazole-5-carbonyl)-6-(2-methylox...) Show SMILES Cc1nc(co1)-c1ccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2c1 Show InChI InChI=1S/C26H24N4O4/c1-15-9-18(10-19-13-27-29-24(15)19)25(32)30-7-5-26(6-8-30)12-22(31)20-11-17(3-4-23(20)34-26)21-14-33-16(2)28-21/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair