BDBM50315096 (R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea::CHEMBL1092914
SMILES: C[C@@H]1COCCN1c1nc(nc(n1)-c1ccc(NC(=O)Nc2cccnc2)cc1)C1CCOCC1
InChI Key: InChIKey=RCOCUXUGYPOUDK-QGZVFWFLSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM50315096 ((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 593 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assay | Bioorg Med Chem Lett 20: 2654-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.029 BindingDB Entry DOI: 10.7270/Q2959HQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Rattus norvegicus) | BDBM50315096 ((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISA | Bioorg Med Chem Lett 20: 2654-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.029 BindingDB Entry DOI: 10.7270/Q2959HQ5 | |||||||||||
More data for this Ligand-Target Pair |