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BDBM50315107 4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-5-yl)piperidine-1-sulfonamide::CHEMBL1089520

SMILES: NS(=O)(=O)N1CCC(CC1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1

InChI Key: InChIKey=KQAVUCRLPGIYGA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50315107   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase p38


(Homo sapiens (Human))
BDBM50315107
PNG
(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Show SMILES NS(=O)(=O)N1CCC(CC1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN5O2S/c20-16-3-1-14(2-4-16)18-17(13-5-9-22-10-6-13)19(24-23-18)15-7-11-25(12-8-15)28(21,26)27/h1-6,9-10,15H,7-8,11-12H2,(H,23,24)(H2,21,26,27)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.65E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation counting


Bioorg Med Chem Lett 20: 2634-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.047
BindingDB Entry DOI: 10.7270/Q21N818H
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50315107
PNG
(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Show SMILES NS(=O)(=O)N1CCC(CC1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN5O2S/c20-16-3-1-14(2-4-16)18-17(13-5-9-22-10-6-13)19(24-23-18)15-7-11-25(12-8-15)28(21,26)27/h1-6,9-10,15H,7-8,11-12H2,(H,23,24)(H2,21,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation counting


Bioorg Med Chem Lett 20: 2634-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.047
BindingDB Entry DOI: 10.7270/Q21N818H
More data for this
Ligand-Target Pair