BDBM50315595 CHEMBL1089440::N-(2-(furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)hexanamide
SMILES: O=C(Nc1ccccc1)Nc1nc(Oc2ccccc2)nc2nc(nn12)-c1ccco1
InChI Key: InChIKey=OAANTUPREZEYHE-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Adenosine Receptors A2a (A2a) (Rattus norvegicus (rat)) | BDBM50315595 (CHEMBL1089440 | N-(2-(furan-2-yl)-5-phenoxy-[1,2,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 38.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National University of Singapore Curated by ChEMBL | Assay Description Displacement of [3H]CGS21680 from adenosine A2A receptor in rat striatal membrane | Bioorg Med Chem 18: 2524-36 (2010) Article DOI: 10.1016/j.bmc.2010.02.039 BindingDB Entry DOI: 10.7270/Q2P84C13 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A3 (Homo sapiens (Human)) | BDBM50315595 (CHEMBL1089440 | N-(2-(furan-2-yl)-5-phenoxy-[1,2,4...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 633 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National University of Singapore Curated by ChEMBL | Assay Description Displacement of [125I]-I-AB-MECA from human adenosine A3 receptor expressed in CHO cells | Bioorg Med Chem 18: 2524-36 (2010) Article DOI: 10.1016/j.bmc.2010.02.039 BindingDB Entry DOI: 10.7270/Q2P84C13 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM50315595 (CHEMBL1089440 | N-(2-(furan-2-yl)-5-phenoxy-[1,2,4...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.87E+3 | n/a | n/a | n/a | n/a |
National University of Singapore Curated by ChEMBL | Assay Description Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity | Bioorg Med Chem 18: 2524-36 (2010) Article DOI: 10.1016/j.bmc.2010.02.039 BindingDB Entry DOI: 10.7270/Q2P84C13 | |||||||||||
More data for this Ligand-Target Pair |