BDBM50315835 2-(2,5-dimethoxyphenyl)-N-(6-methyl-3-styryl-1H-indazol-5-yl)acetamide::CHEMBL1091617

SMILES: COc1ccc(OC)c(CC(=O)Nc2cc3c(\C=C\c4ccccc4)n[nH]c3cc2C)c1

InChI Key: InChIKey=KAHHZLXTLVPZAC-PKNBQFBNSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50315835   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50315835 (2-(2,5-dimethoxyphenyl)-N-(6-methyl-3-styryl-1H-in...) Show SMILES COc1ccc(OC)c(CC(=O)Nc2cc3c(\C=C\c4ccccc4)n[nH]c3cc2C)c1 Show InChI InChI=1S/C26H25N3O3/c1-17-13-24-21(22(28-29-24)11-9-18-7-5-4-6-8-18)16-23(17)27-26(30)15-19-14-20(31-2)10-12-25(19)32-3/h4-14,16H,15H2,1-3H3,(H,27,30)(H,28,29)/b11-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
S*BIO Pte. Ltd Curated by ChEMBL					Assay Description Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminnescence				Bioorg Med Chem Lett 20: 2443-7 (2010) Article DOI: 10.1016/j.bmcl.2010.03.018 BindingDB Entry DOI: 10.7270/Q24B31HK
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50315835 (2-(2,5-dimethoxyphenyl)-N-(6-methyl-3-styryl-1H-in...) Show SMILES COc1ccc(OC)c(CC(=O)Nc2cc3c(\C=C\c4ccccc4)n[nH]c3cc2C)c1 Show InChI InChI=1S/C26H25N3O3/c1-17-13-24-21(22(28-29-24)11-9-18-7-5-4-6-8-18)16-23(17)27-26(30)15-19-14-20(31-2)10-12-25(19)32-3/h4-14,16H,15H2,1-3H3,(H,27,30)(H,28,29)/b11-9+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
S*BIO Pte. Ltd Curated by ChEMBL					Assay Description Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assay				Bioorg Med Chem Lett 20: 2443-7 (2010) Article DOI: 10.1016/j.bmcl.2010.03.018 BindingDB Entry DOI: 10.7270/Q24B31HK
					More data for this Ligand-Target Pair