null
SMILES: Cc1c(sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1)-c1cccc(c1)S(C)(=O)=O
InChI Key: InChIKey=ONCWMCNSCPKGPD-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM50315915 (5-(7-methyl-6-(3-(methylsulfonyl)phenyl)-4-morphol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay | Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX | |||||||||||
More data for this Ligand-Target Pair |