BDBM50316186 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-(aminomethyl)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol::CHEMBL1098241

SMILES: CCn1c(nc2c(nc(CN)cc12)C#CC(C)(C)O)-c1nonc1N

InChI Key: InChIKey=SAJJWJQNKYDEPD-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50316186   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM50316186 (4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-(aminomethyl...) Show SMILES CCn1c(nc2c(nc(CN)cc12)C#CC(C)(C)O)-c1nonc1N Show InChI InChI=1S/C16H19N7O2/c1-4-23-11-7-9(8-17)19-10(5-6-16(2,3)24)12(11)20-15(23)13-14(18)22-25-21-13/h7,24H,4,8,17H2,1-3H3,(H2,18,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of AKT3				Bioorg Med Chem Lett 19: 1508-11 (2009) Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50316186 (4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-(aminomethyl...) Show SMILES CCn1c(nc2c(nc(CN)cc12)C#CC(C)(C)O)-c1nonc1N Show InChI InChI=1S/C16H19N7O2/c1-4-23-11-7-9(8-17)19-10(5-6-16(2,3)24)12(11)20-15(23)13-14(18)22-25-21-13/h7,24H,4,8,17H2,1-3H3,(H2,18,22)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of AKT				Bioorg Med Chem Lett 19: 1508-11 (2009) Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50316186 (4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-(aminomethyl...) Show SMILES CCn1c(nc2c(nc(CN)cc12)C#CC(C)(C)O)-c1nonc1N Show InChI InChI=1S/C16H19N7O2/c1-4-23-11-7-9(8-17)19-10(5-6-16(2,3)24)12(11)20-15(23)13-14(18)22-25-21-13/h7,24H,4,8,17H2,1-3H3,(H2,18,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of AKT2				Bioorg Med Chem Lett 19: 1508-11 (2009) Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50316186 (4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-(aminomethyl...) Show SMILES CCn1c(nc2c(nc(CN)cc12)C#CC(C)(C)O)-c1nonc1N Show InChI InChI=1S/C16H19N7O2/c1-4-23-11-7-9(8-17)19-10(5-6-16(2,3)24)12(11)20-15(23)13-14(18)22-25-21-13/h7,24H,4,8,17H2,1-3H3,(H2,18,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of GSK3beta phosphorylation in human BT474 cells				Bioorg Med Chem Lett 19: 1508-11 (2009) Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7
					More data for this Ligand-Target Pair