BDBM50316775 2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-benzyl-1H-indole-3-yl]ethanamine hydrochloride::CHEMBL1094196
SMILES: COc1ccc(cc1)-c1ccc(Cn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1
InChI Key: InChIKey=FVGFBWAPMMXCST-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human)) | BDBM50316775 (2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA | Bioorg Med Chem 18: 3387-402 (2010) Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50316775 (2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP | Bioorg Med Chem 18: 3387-402 (2010) Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin-like growth factor 1 receptor (Homo sapiens (Human)) | BDBM50316775 (2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP | Bioorg Med Chem 18: 3387-402 (2010) Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50316775 (2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Inhibition of EGFR after 30 mins by chemiluminescence ELISA | Bioorg Med Chem 18: 3387-402 (2010) Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT | |||||||||||
More data for this Ligand-Target Pair |